Health / Pharmaceuticals
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45-1 Ramsey Road, Shirley, New York 11967, USA, Shirley
Homology modeling (also known as comparative modeling) is to date the most reliable and well-established computational approach for predicting protein structures. In this method one or more experimental three-dimensional structures of related homologous proteins are identified and used as templates based on which an atomic-resolution model of the "target" protein is built from its amino acid sequence. It has been shown that three-dimensional protein structure is evolutionarily more conserved than would be expected on the basis of sequence conservation alone. Thus even proteins that have diverged appreciably in sequence but still share detectable similarity will also share common structural properties... read more
Homology modeling (also known as comparative modeling) is to date the most reliable and well-established computational approach for predicting protein structures. In this method one or more experimental three-dimensional structures of related homologous proteins are identified and used as templates based on which an atomic-resolution model of the "target" protein is built from its amino acid sequence. It has been shown that three-dimensional protein structure is evolutionarily more conserved than would be expected on the basis of sequence conservation alone. Thus even proteins that have diverged appreciably in sequence but still share detectable similarity will also share common structural properties... read more
45-1 Ramsey Road, Shirley, New York 11967, USA, Shirley
The process of drug discovery involves the identification of molecular candidates synthesis and test of chemical compounds for their pharmaceutical efficacy. Computer-Aided Drug Design (CADD) is a specialized sub-discipline of rational drug design that uses computational methods to investigate/predict drug-receptor interactions. Quantum mechanics (QM) is an essential tool in CADD research. High-throughput in silico screening of ligand binding (such as docking or QSAR) can significant reduce the time required for compound discovery and optimization. However these rapid methods often lack the accuracy in exploring the binding mechanism details. On the contrary we can obtain a more accurate representation of molecular... read more
The process of drug discovery involves the identification of molecular candidates synthesis and test of chemical compounds for their pharmaceutical efficacy. Computer-Aided Drug Design (CADD) is a specialized sub-discipline of rational drug design that uses computational methods to investigate/predict drug-receptor interactions. Quantum mechanics (QM) is an essential tool in CADD research. High-throughput in silico screening of ligand binding (such as docking or QSAR) can significant reduce the time required for compound discovery and optimization. However these rapid methods often lack the accuracy in exploring the binding mechanism details. On the contrary we can obtain a more accurate representation of molecular... read more
45-1 Ramsey Road, Shirley, New York 11967, USA, Shirley
Profacgen offers a comprehensive list of high-throughput screening services to specifically and efficiently identify potential enzyme substrates activators and inhibitors. Enzymes participate in numerous physiological activities including signal transduction cell surface recognition and protein modification. To determine possible targets of an enzyme Profacgen has developed a highly efficient screening system to select candidate substrates inhibitors or activators by detection of fluorescence chemo-luminescence or isotopic signal. Generally the candidate molecules can be selected or synthesized and then immobilized on a solid surface. Detection is performed after incubation with the target enzyme according to the specific experimental design.... read more
Profacgen offers a comprehensive list of high-throughput screening services to specifically and efficiently identify potential enzyme substrates activators and inhibitors. Enzymes participate in numerous physiological activities including signal transduction cell surface recognition and protein modification. To determine possible targets of an enzyme Profacgen has developed a highly efficient screening system to select candidate substrates inhibitors or activators by detection of fluorescence chemo-luminescence or isotopic signal. Generally the candidate molecules can be selected or synthesized and then immobilized on a solid surface. Detection is performed after incubation with the target enzyme according to the specific experimental design.... read more
45-1 Ramsey Road, Shirley, New York 11967, USA, Shirley
The development and validation of immunogenicity assays is under constant discussion within the industry. Based on our GLP-compliant service laboratories Profacgen is involved in international workshops and has R&D programs to keep ahead of the latest developments in this area so that we can best help our customers to accelerate their drug discovery and development programs. Immunogenicity assays can be challenging due to interferences originating from the sample matrix drug interference or target interference. In order to design a robust immunogenicity assay it is important to start with the appropriate assay platform and high-quality reagents. There are two predominant strategies... read more
The development and validation of immunogenicity assays is under constant discussion within the industry. Based on our GLP-compliant service laboratories Profacgen is involved in international workshops and has R&D programs to keep ahead of the latest developments in this area so that we can best help our customers to accelerate their drug discovery and development programs. Immunogenicity assays can be challenging due to interferences originating from the sample matrix drug interference or target interference. In order to design a robust immunogenicity assay it is important to start with the appropriate assay platform and high-quality reagents. There are two predominant strategies... read more
45-1 Ramsey Road, Shirley, New York 11967, USA, Shirley
Profacgen provides stable cell line development service for industrial protein manufacturing. We offer various cell line development options which allow the maximum flexibility in reaching our client’s expectations and accelerate the preclinical drug development process. Stable expression line construction is recommended for reproducible and cost-effective protein production when large amount of recombinant protein is required. Profacgen guarantees well-developed stable cell lines with robust and reproducible production of the target protein.... read more
Profacgen provides stable cell line development service for industrial protein manufacturing. We offer various cell line development options which allow the maximum flexibility in reaching our client’s expectations and accelerate the preclinical drug development process. Stable expression line construction is recommended for reproducible and cost-effective protein production when large amount of recombinant protein is required. Profacgen guarantees well-developed stable cell lines with robust and reproducible production of the target protein.... read more
45-1 Ramsey Road, Shirley, New York 11967, USA, Shirley
Profacgen takes advantage of the computational modeling capabilities to predict potential PTM sites in the protein as well as to model the side chain and main chain conformations to reflect the changes resulted from common post-translation modification. Our algorithms are trained using existing PTMs observed in the Protein Data Bank and proven to be fast and accurate.... read more
Profacgen takes advantage of the computational modeling capabilities to predict potential PTM sites in the protein as well as to model the side chain and main chain conformations to reflect the changes resulted from common post-translation modification. Our algorithms are trained using existing PTMs observed in the Protein Data Bank and proven to be fast and accurate.... read more
155 Federal Street, Suite 700, Boston
Bioamine is a kind of low molecular weight compounds containing nitric fatty group or heterocycle group. Depending on the composition of amine bioamine can be divided into two classes monoamine and polyamine. Monoamine plays a role in muscular and blood vessel relaxation and regulates cerebral cortex activity. Polyamine mainly promotes synthesis of macromolecules including DNA RNA and proteins and accelerates development and growth. MtoZ Biolabs offers targeted bioamine analysis service using ACQUITY UPLC/TripleQuad5500 (Waters/AB Sciex) which have characteristics of high accuracy specificity and sensitivity. We guarantee accurate analysis of bioamine even in low abundance. With our optimized sample preparation methods... read more
Bioamine is a kind of low molecular weight compounds containing nitric fatty group or heterocycle group. Depending on the composition of amine bioamine can be divided into two classes monoamine and polyamine. Monoamine plays a role in muscular and blood vessel relaxation and regulates cerebral cortex activity. Polyamine mainly promotes synthesis of macromolecules including DNA RNA and proteins and accelerates development and growth. MtoZ Biolabs offers targeted bioamine analysis service using ACQUITY UPLC/TripleQuad5500 (Waters/AB Sciex) which have characteristics of high accuracy specificity and sensitivity. We guarantee accurate analysis of bioamine even in low abundance. With our optimized sample preparation methods... read more
155 Federal Street, Suite 700, Boston
Sequential Window Acquisition of all Theoretical fragment ions (SWATH) is a brand new mass spectrometry technology co-developed by Dr. Ruedi Aebersold research group (ETH Zürich) and AB SCIEX. SWATH data is an independent acquisition (DIA) technique. Unlike data dependent acquisition technique which only selects certain MS spectrum for MS/MS detection SWATH analyzes all MS and MS/MS spectra allowing detection of virtually all detectable proteins in a sample. In SWATH technology MS spectra are divided into several narrow windows and peptides in each window are sequentially analyzed equally followed by MS/MS analysis. SWATH technique combines the high-throughput quality of shotgun proteomics... read more
Sequential Window Acquisition of all Theoretical fragment ions (SWATH) is a brand new mass spectrometry technology co-developed by Dr. Ruedi Aebersold research group (ETH Zürich) and AB SCIEX. SWATH data is an independent acquisition (DIA) technique. Unlike data dependent acquisition technique which only selects certain MS spectrum for MS/MS detection SWATH analyzes all MS and MS/MS spectra allowing detection of virtually all detectable proteins in a sample. In SWATH technology MS spectra are divided into several narrow windows and peptides in each window are sequentially analyzed equally followed by MS/MS analysis. SWATH technique combines the high-throughput quality of shotgun proteomics... read more
155 Federal Street, Suite 700, Boston
Similar to SILAC technique Dimethyl labeling is also an isotopic labeling method. However Dimethyl labeling is a chemical labeling process and labels lysine or the N-terminal amino acid residues on peptide instead of labeling proteins. Except for the difference in labeling method SILAC and Dimethyl labeling technique have comparable sensitivity and accuracy and are being more and more widely used in relative proteomics studies. MtoZ Biolabs has developed a specialized platform equipped with Q Exactive HF (Thermo Fisher) Orbitrap Fusion and Orbitrap Fusion Lumos mass spectrometers equipped with Nano-LC for SILAC/Dimethyl analysis service.... read more
Similar to SILAC technique Dimethyl labeling is also an isotopic labeling method. However Dimethyl labeling is a chemical labeling process and labels lysine or the N-terminal amino acid residues on peptide instead of labeling proteins. Except for the difference in labeling method SILAC and Dimethyl labeling technique have comparable sensitivity and accuracy and are being more and more widely used in relative proteomics studies. MtoZ Biolabs has developed a specialized platform equipped with Q Exactive HF (Thermo Fisher) Orbitrap Fusion and Orbitrap Fusion Lumos mass spectrometers equipped with Nano-LC for SILAC/Dimethyl analysis service.... read more
325 LINDEN ST MODESTO, london
Tel: 844 293 2835
Zop 7.5 MG (Zopiclone) is a sleeping pill which belongs to a medicinal class known as Z drug which helps to treat insomnia.... read more
Tel: 844 293 2835
Zop 7.5 MG (Zopiclone) is a sleeping pill which belongs to a medicinal class known as Z drug which helps to treat insomnia.... read more
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