Health / Pharmaceuticals
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45-1 Ramsey Road, Shirley, New York 11967, USA, Shirley
Creative BioMart has a revolutionary new platform combining affinity tag binding with inert porous materials designed specifically for biocatalysis applications in any organic solvent or aqueous buffer. If your enzyme can be affinity tagged it can be immobilized in Creative BioMart. Creative BioMart provides a highly efficient way to go from cell extract or cell culture supernatant to a versatile and robust immobilized pure enzyme preparation in a single step. Convenience: Minuscule amounts of protein dissolve in the reaction so workup can be much easier. Upon completion reaction mixtures typically contain only solvent and reaction products. Economy: The immobilized enzyme... read more
Creative BioMart has a revolutionary new platform combining affinity tag binding with inert porous materials designed specifically for biocatalysis applications in any organic solvent or aqueous buffer. If your enzyme can be affinity tagged it can be immobilized in Creative BioMart. Creative BioMart provides a highly efficient way to go from cell extract or cell culture supernatant to a versatile and robust immobilized pure enzyme preparation in a single step. Convenience: Minuscule amounts of protein dissolve in the reaction so workup can be much easier. Upon completion reaction mixtures typically contain only solvent and reaction products. Economy: The immobilized enzyme... read more
45-1 Ramsey Road, Shirley, New York 11967, USA, Shirley
The protein encoded by this gene is the CD3-epsilon polypeptide which together with CD3-gamma -delta and -zeta and the T-cell receptor alpha/beta and gamma/delta heterodimers forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.... read more
The protein encoded by this gene is the CD3-epsilon polypeptide which together with CD3-gamma -delta and -zeta and the T-cell receptor alpha/beta and gamma/delta heterodimers forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.... read more
45-1 Ramsey Road, Shirley, New York 11967, USA, Shirley
CD4 is a single chain transmembraneous glycoprotein (59 kDa) which belongs to the immunoglobulin superfamily. CD4 is present on a subset of T lymphocytes ("helper/inducer" T cells) and is also expressed at a lower level on monocytes tissue macrophages and granulocytes. The antigen is involved in binding to MHC class II molecules. The intracellular domain of the antigen is associated with p56lck protein tyrosine kinase. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits: CD3 gamma CD3 delta CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins... read more
CD4 is a single chain transmembraneous glycoprotein (59 kDa) which belongs to the immunoglobulin superfamily. CD4 is present on a subset of T lymphocytes ("helper/inducer" T cells) and is also expressed at a lower level on monocytes tissue macrophages and granulocytes. The antigen is involved in binding to MHC class II molecules. The intracellular domain of the antigen is associated with p56lck protein tyrosine kinase. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits: CD3 gamma CD3 delta CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins... read more
45-1 Ramsey Road, Shirley, New York 11967, USA, Shirley
DNAM-1 (CD226) is a ~65 kD glycoprotein expressed on cell surface of T cells NK cells monocytes/macrophages platelets and megakaryocytes and a subset of B cells and a member of the immunoglobulin (Ig)-superfamily containing 2 Ig-like domains of the V-s... read more
DNAM-1 (CD226) is a ~65 kD glycoprotein expressed on cell surface of T cells NK cells monocytes/macrophages platelets and megakaryocytes and a subset of B cells and a member of the immunoglobulin (Ig)-superfamily containing 2 Ig-like domains of the V-s... read more
45-1 Ramsey Road, Shirley, New York 11967, USA, Shirley
Serum albumin the main protein of plasma has a good binding capacity for water Ca(2+) Na(+) K(+) fatty acids hormones bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma typically binds about 80% of all plasma zinc.... read more
Serum albumin the main protein of plasma has a good binding capacity for water Ca(2+) Na(+) K(+) fatty acids hormones bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma typically binds about 80% of all plasma zinc.... read more
45-1 Ramsey Road, Shirley, New York 11967, USA, Shirley
The protein encoded by this gene pre-angiotensinogen or angiotensinogen precursor is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product angiotensin I is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension and can cause renal tubular dysgenesis a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial... read more
The protein encoded by this gene pre-angiotensinogen or angiotensinogen precursor is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product angiotensin I is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension and can cause renal tubular dysgenesis a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial... read more
45-1 Ramsey Road, Shirley, New York 11967, USA, Shirley
Activin receptor type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins composed of a ligand-binding extracellular domain with cysteine-rich region a transmembrane domain and a cytoplasmic... read more
Activin receptor type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins composed of a ligand-binding extracellular domain with cysteine-rich region a transmembrane domain and a cytoplasmic... read more
45-1 Ramsey Road, Shirley, New York 11967, USA, Shirley
This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility structure and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins.... read more
This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility structure and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins.... read more
45-1 Ramsey Road, Shirley, New York 11967, USA, Shirley
As a global leader of drug screening and profiling services Profacgen offers a comprehensive panel of services designed to speed and simplify your drug discovery research. Our biochemical and cell-based screening services are considered excellent tools to quickly narrow down a large pool of candidates to a much smaller one to identify potential therapeutics and to predict potency. With all screening and profiling services profacgen will provide you comprehensive report with method reagent detailed protocol and analyzed data. Most of the key reagents used in above services are developed by ourselves and assay protocols were validated thoroughly. You can be... read more
As a global leader of drug screening and profiling services Profacgen offers a comprehensive panel of services designed to speed and simplify your drug discovery research. Our biochemical and cell-based screening services are considered excellent tools to quickly narrow down a large pool of candidates to a much smaller one to identify potential therapeutics and to predict potency. With all screening and profiling services profacgen will provide you comprehensive report with method reagent detailed protocol and analyzed data. Most of the key reagents used in above services are developed by ourselves and assay protocols were validated thoroughly. You can be... read more
45-1 Ramsey Road, Shirley, New York 11967, USA, Shirley
The three-dimensional structure of a protein provides essential information about its biological function and facilitates the design of therapeutic drugs that specifically bind to the protein target. Recent years have witnessed a tremendous increase in the number of experimentally determined protein structures. It is however still generally tedious and time-consuming to solve protein structures with experimental approaches. Therefore computational approaches represent an alternative and supplement to experimental methods to obtain three-dimensional structure of a protein. Profacgen takes advantage of computational modeling methods to predict the three-dimensional structure of proteins of your interest. We have extensive experiences with the modeling of... read more
The three-dimensional structure of a protein provides essential information about its biological function and facilitates the design of therapeutic drugs that specifically bind to the protein target. Recent years have witnessed a tremendous increase in the number of experimentally determined protein structures. It is however still generally tedious and time-consuming to solve protein structures with experimental approaches. Therefore computational approaches represent an alternative and supplement to experimental methods to obtain three-dimensional structure of a protein. Profacgen takes advantage of computational modeling methods to predict the three-dimensional structure of proteins of your interest. We have extensive experiences with the modeling of... read more
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