Homology Modeling

Homology modeling (also known as comparative modeling) is, to date, the most reliable and well-established computational approach for predicting protein structures. In this method, one or more experimental three-dimensional structures of related homologous proteins are identified and used as templates, based on which an atomic-resolution model of the "target" protein is built from its amino acid sequence. It has been shown that three-dimensional protein structure is evolutionarily more conserved than would be expected on the basis of sequence conservation alone. Thus, even proteins that have diverged appreciably in sequence but still share detectable similarity will also share common structural properties, particularly the overall folding.
Profacgen takes advantage of the homology modeling method to help customers predict the three-dimensional structure of proteins of interest. We have extensive experience with the modeling of various monomeric and oligomeric proteins. The resultant structural models are all quality validated and can be used for functional annotation of genes, molecular docking and directing further experimental work such as protein engineering and drug design.

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