Introduction
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
Contact Info
Address:
45-1 Ramsey Road, Shirley, NY 11967, USA
Shirley
NY 11967
United States
Shirley
NY 11967
United States
Tel:
6316197922
Website:
http://www.creativebiomart.net/symbolsearch_PTEN.htm
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