Introduction
In inflammatory diseases, the inflammatory stimuli that induce chemokine expression can vary widely and include viral and bacterial pathogens and toxic chemicals. Chemokines that are released by resident tissue cells and cells of the vessel wall are responsible for inducing the strong adhesive, integrin-mediated interactions between marginating leukocytes and the endothelium. Adherent leukocytes will migrate through the endothelial cell layer, and will be attracted to the inflammatory site by a chemokine gradient which has been established within the inflammed tissue. Initially, this process is a protective one, causing only minimal damage in the interests of clearing up the infection or irritant. However, this immune response can become an overwhelming attack on healthy tissue, contributing to the damage that is seen in a wide range of inflammatory diseases.
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Address:
45-1 Ramsey Road, Shirley, NY 11967, USA
Shirley
NY 11967
United States
Shirley
NY 11967
United States
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Website:
http://www.creativebiomart.net/gene-family/49-chemokines-and-diseases.htm
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