CD3D
2 RESULTS
45-1 Ramsey Road, Shirley, New York 11967, USA, Shirley
CD4 is a single chain transmembraneous glycoprotein (59 kDa) which belongs to the immunoglobulin superfamily. CD4 is present on a subset of T lymphocytes ("helper/inducer" T cells) and is also expressed at a lower level on monocytes tissue macrophages and granulocytes. The antigen is involved in binding to MHC class II molecules. The intracellular domain of the antigen is associated with p56lck protein tyrosine kinase. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits: CD3 gamma CD3 delta CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins... read more
CD4 is a single chain transmembraneous glycoprotein (59 kDa) which belongs to the immunoglobulin superfamily. CD4 is present on a subset of T lymphocytes ("helper/inducer" T cells) and is also expressed at a lower level on monocytes tissue macrophages and granulocytes. The antigen is involved in binding to MHC class II molecules. The intracellular domain of the antigen is associated with p56lck protein tyrosine kinase. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits: CD3 gamma CD3 delta CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins... read more
45-1 Ramsey Road, Shirley, New York 11967, USA, Shirley
The protein encoded by this gene is the CD3-epsilon polypeptide which together with CD3-gamma -delta and -zeta and the T-cell receptor alpha/beta and gamma/delta heterodimers forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.... read more
The protein encoded by this gene is the CD3-epsilon polypeptide which together with CD3-gamma -delta and -zeta and the T-cell receptor alpha/beta and gamma/delta heterodimers forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.... read more
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