protein crystallization

X-ray crystallography is a scientific technique of determining the positions and arrangements of atoms in a crystal. Beams of X-ray diffract into various specific directions when they strike a crystal, forming a diffraction pattern that can be interpreted into the three-dimensional structure of macromolecules. Since the first determined protein structure – myoglobin – in 1958, X-ray crystallography has become the most significant and useful tool for protein structure determination. Nowadays, more than 115,000 protein structures have been deposited into the Protein Data Bank and about 90% of them are by X-ray, suggesting its overwhelming advantages in protein structure study.

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