Potassium voltage-gated channel Inhibitor

Potassium voltage-gated channel (abbreviated as KCNA3) belongs to shaker-related subfamily of member 3. KCNA3 encodes the voltage-gated Kv1.3 channel, which is expressed in T and B lymphocytes. All human T cells express roughly 300 Kv1.3 channels per cell. From a functional and structural point of view, KCNA3 is the most complex voltage-gated ion channel. As a central channel with a divergent filter property consisting of a homotetramer and four transmembrane protein subunits, KCNA3 channel can conduct ions, which can make the potassium ions pass smoothly. There will be one or two P-loop regions on each transmembrane protein subunit. P-loop is a highly guarded P loopback region (Fig. 1). KCNA3 has multiple functions such as regulation of neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction and cell volume.

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