Introduction
Lymphocyte function-associated antigen 1(LFA-1) is part of the family of leukocyte integrins that are recognised by their common β-chains (β2, CD18). It is found on all T-cells and also on B-cells, macrophages and neutrophils and is involved in recruitment to the site of infection. It binds to ICAM-1 on antigen-presenting cells and functions as an adhesion molecule. It is the first to bind T-cells to antigen-presenting cells and initially binds weakly.
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