Introduction
Synthesis challenges and strategies of long peptides
There are some challenges to the synthesis of long peptides, such as a large cumulative effect of yield, which can result in slow or incomplete coupling and/or reverse protection during the synthesis, as well as low solubility in the assembly of the protected peptide.
For the synthesis of long peptides, there are generally two ways of gradual growth and fragment condensation. The former starts with the starting amino acid (or peptide) and grows one amino acid per connection. The latter is obtained by condensation of a C-terminal protective peptide and an N-terminal protective peptide, and the new peptide chain with the sum of the two.
There are some challenges to the synthesis of long peptides, such as a large cumulative effect of yield, which can result in slow or incomplete coupling and/or reverse protection during the synthesis, as well as low solubility in the assembly of the protected peptide.
For the synthesis of long peptides, there are generally two ways of gradual growth and fragment condensation. The former starts with the starting amino acid (or peptide) and grows one amino acid per connection. The latter is obtained by condensation of a C-terminal protective peptide and an N-terminal protective peptide, and the new peptide chain with the sum of the two.
Contact Info
Address:
45-16 Ramsey Road, Shirley, NY 11967, USA
Shirley, NY
NY 11967
United States
Shirley, NY
NY 11967
United States
Tel:
Website:
https://www.creative-peptides.com/services/long-peptides-synthesis.html
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