Liver Disease Models

Liver diseases occur frequently and are life-threatening for humans. The underlying causes vary from viral infections, autoimmune diseases and intoxications (including alcohol abuse) to unbalanced diets. Although the liver can regenerate without injury in the early stages of the disease, it cannot heal in the later stages and may require an organ transplant. We must understand the underlying mechanisms in order to design and develop new drugs in this area. Mature and stable animal models to mimic human liver diseases could thus play an important role.

Creative Bioarray established a variety of animal models for liver diseases, including acute liver injury, chronic liver injury, chronic fatty liver disease, alcoholic steatohepatitis (ASH) and nonalcoholic steatohepatitis (NASH). These models have unique characteristics and etiologies of human liver diseases to help clients assess the efficacy of new compounds in related clinical liver diseases and better understand the underlying mechanisms of new drugs.

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