Introduction
It reacts with CD119, the alpha chain of the interferon gamma (IFN-gamma) receptor. This receptor is expressed by mouse leukocytes, endothelial, and epithelial cells, but not by mature erythrocytes. This antibody recognizes an epitope (susceptible to certain fixatives) in the ligand-binding site of the receptor. It can block the binding of mouse IFN-gamma; therefore, it can inhibit IFN-gamma mediated effects including the activation of mouse macrophages for tumor cell killing. IFN-gamma has been reported to induce the expression of Ly-6A/E antigen on cell lines and normal B lymphocytes, and the antibody is capable of inhibiting the IFN-gamma.induced expression of Ly-6A/E on the mouse B lymphoma line A20. The binding of the antibody to CD119 is inhibited by IFN-gamma. This antibody reportedly does not have any agonist effect.
Contact Info
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45-1 Ramsey Road, Shirley, New York 11967, USA
Shirley
New York 11967
United States
Shirley
New York 11967
United States
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https://www.creativebiomart.net/symbolsearch_Ifngr1.htm
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