IP3/IP1 Assay

GPCRs transmit information within cells via two major signaling pathways: regulation of cAMP levels and increases in intracellular Ca2+ triggered by inositol 1, 4, 5- triphosphate (IP3). These signaling pathways are activated by specific G protein associated with the receptor. Activation of Gs or Gi coupled receptor results in an increase or decrease in cAMP levels, respectively. While activation of Gq coupled receptor activates phospholipase C (PLC), which converts PIP2 into DAG and IP3. The metabolic pathway of IP3 is very complicated, as IP3 can either be directly hydrolyzed or be first phosphorylated to generate D-myo-inositol 1, 3, 4, 5-tetrakisphosphate (IP4) before being degraded. These processes involve several phosphatases, leading to the formation of D-myo-inositol bisphosphates (IP2) and D-myo-inositol monophosphates (IP1), which can be phosphorylated at different positions on the inositol ring. Finally, inositol monophosphatase (IMPase) degrades IP1 into myo-inositol.

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