GPCR Screening Services

G-protein-coupled receptors (GPCRs) play an incredible role in a range of functions in the human body, and increased understanding of these receptors has greatly affected modern medicine. In fact, researchers estimate that between one-third and one-half of the marketed drugs act by binding to GPCRs.

GPCRs mediate many important physiological functions and are considered to be one of the most successful therapeutic targets for a broad spectrum of diseases. The design and application of high-throughput GPCR assays are critical for early drug discovery, which allow the cost-effective screening of large compound libraries to identify novel drug candidates. Early functional GPCR assays rely primarily on the measurement of G-protein-mediated 2nd messenger. Taking advantage of the continuously deepening understanding of GPCR signal transduction, many G-protein-independent pathways are used to detect the activity of GPCRs, and may provide additional information for the functional selectivity of candidate compounds. With the combination of automated imaging systems and label-free detection systems, such assays are now suitable for high-throughput screening (HTS).

Creative Bioarray offers a comprehensive selection of binding and functional GPCR assays to meet the GPCR drug discovery research needs of both chemists and biologists.

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Monday	Open	9:00am	5:00pm
Tuesday	Open	9:00am	5:00pm
Wednesday	Open	9:00am	5:00pm
Thursday	Open	9:00am	5:00pm
Friday	Open	9:00am	5:00pm
Saturday	Open	9:00am	5:00pm
Sunday	Open