Cyclin D1 Inhibitor

Inhibition of cyclin D1

Cyclin D1 (Cyclin D1) acts as a regulatory subunit of CDK4 and CDK6 (Cyclin D1/CDK4 and Cyclin D1/CDK6) and is required for G1 to S phase transition. CDK4-cyclinD1 inhibitor can inhibit DNA synthesis and cause G1 arrest. It can also block the phosphorylation of pRb protein in tumor cells, thereby inhibiting cell proliferation and anti-tumor effect.

Cyclin D1 and diseases

As one of the cell cycle regulators, cyclin D1 can shorten the cell cycle G1 phase, allow cells to enter S phase in advance, accelerate cell growth, and promote tumor development. Cyclin D1 is required for normal cell division and is overexpressed in patients with oral cancer to promote cancer cell proliferation. There are factors that promote the proliferation of cancer cells in DNA, RNA and translation. Excessive expression of cyclin D1 is found in B-cell lymphomas and common malignant tumors such as the breast and esophagus. Cyclin D1 and proliferating cell nuclear antigen (Ki-67) play an important role in the regulation of cell proliferation and apoptosis in EOC cells, which can cause abnormal cell proliferation and ultimately lead to the occurrence and development of malignant tumors.

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