Apoptosis Execution pathway

Apoptosis execution pathway is the same terminal of extrinsic, intrinsic, and perforin/granzyme apoptosis pathways, leading to the morphological and biochemical changes that characterize apoptosis. As the final stage of apoptosis, it causes cell shrinkage, formation of cytoplasmic blebs and apoptotic bodies and finally phagocytosis of the apoptotic bodies by adjacent parenchymal cells, neoplastic cells or macrophages.