Ames Test

Creative Bioarray provides Bacterial Reverse Mutation Test (Ames test, OECD 471) using 7Salmonella typhimurium strains and 2 Escherichia coli strains to assess the mutagenic potential of test articles. This assay is available under either Good Laboratory Practice (GLP) or Non-GLP conditions.

Point mutations in the genome are the cause of many genetic diseases including various tumors that involve point mutations in oncogenes and tumor suppressor genes. Determining the mutagenic potency of compounds using an indicative method is of considerable importance.

The bacterial reverse mutation assay (also known as Ames assay) is widely used in genotoxicity screening of test articles for their mutagenic potential (particularly, point mutation-inducing activity) and is regulated in the OECD genetic toxicology test guidelines. In this assay, amino-acid requiring strains of S. typhimurium and E. coli carrying mutations in genes of the histidine and tryptophan operon are used to detect point mutations caused by mutagenic compounds. When reverse mutations occur, the bacteria restore their capability of synthesizing essential amino acids and can be detected by their ability to grow in the absence of the amino acid required by the parent test strain.

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Monday	Open	9:00am	5:00pm
Tuesday	Open	9:00am	5:00pm
Wednesday	Open	9:00am	5:00pm
Thursday	Open	9:00am	5:00pm
Friday	Open	9:00am	5:00pm
Saturday	Open	9:00am	5:00pm
Sunday	Open