Introduction
The development of Alzheimer’s vaccine primarily aims at two targets, amyloid beta (Aβ) and tau protein. Their accumulation during Alzheimer’s disease (AD) progression can cause neuronal damage. Therefore, researchers hope that the immune system is able to recognize the antigenic characteristics of the two proteins and produce antibodies against them.
However, current research indicates that almost all attempts to develop vaccines using Aβ end in disappointment, probably because the vaccine has the wrong immunogen, the B-cell epitope of Aβ, which stimulates an antibody response that releases the neurotoxic soluble Aβ oligomers trapped in plaque, and the use of proinflammatory adjuvants that induce a destructive inflammatory autoimmune response. Thus, the development of a safe and effective Alzheimer’s vaccine that induces protective antibody production requires new strategies, and lessons learned from past vaccine failures should be considered.
However, current research indicates that almost all attempts to develop vaccines using Aβ end in disappointment, probably because the vaccine has the wrong immunogen, the B-cell epitope of Aβ, which stimulates an antibody response that releases the neurotoxic soluble Aβ oligomers trapped in plaque, and the use of proinflammatory adjuvants that induce a destructive inflammatory autoimmune response. Thus, the development of a safe and effective Alzheimer’s vaccine that induces protective antibody production requires new strategies, and lessons learned from past vaccine failures should be considered.
Contact Info
Address:
45-1 Ramsey Road, Shirley, New York 11967, USA
New York
11967
United States
New York
11967
United States
Tel:
1-6316197922
Website:
https://www.creativebiomart.net/alzheimacy/therapeutics/vaccine/
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