Introduction
Genetic mutation is an important factor that contributes to the pathogenesis and development of Alzheimer’s disease (AD). The genetic factors studied include the dominant mutations of genes encoding amyloid-β precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2). Additionally, more and more genes have been found to be potentially associated with AD, such as apolipoprotein E (APOE), glycogen synthase kinase 3 beta (GSK3B), dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A), and Tau. Although many studies on the treatment of AD have not been successful, gene therapy is still considered as a potential way against AD, and some gene-therapy-based therapeutics have entered the clinical trial stage. Existing strategies for gene therapy against AD include gene inactivation, genetic modification, and immunoregulation, etc.
Contact Info
Address:
45-1 Ramsey Road, Shirley, New York 11967, USA
New York
United States
New York
United States
Tel:
Website:
https://www.creativebiomart.net/alzheimacy/therapeutics/gene-therapy/
Hours of operation
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