Introduction
An Overview of 5-lipoxygenase
5-lipoxygenase (5-LOX) is an important kind of dioxygenase and a kind of LOX isozyme in organism. It is widely found in the tissues and blood of most mammals. The molecular weight of 5-lipoxygenase is 75 ~ 80kD, including 673 amino acids. 5-LOX mainly consists of two domains, of which the C2 domain, which is composed of 120 amino acids at the N-terminal, can bind to Ca2+, as well as a large catalytic domain. When stimulated by inflammatory factors, activated cytosolic phosphatase A2 (CPLA2) stimulated membrane phospholipid release of arachidonic acid (AA). At this point, the precursor compound AA will eventually produce leukotrienes (LTs) via the 5-LOX pathway. LTs is an important inflammatory mediator involved in many diseases such as atherosclerosis, cardiovascular disease, heart disease and other pathophysiological processes.
Agonist of 5-lipoxygenase
The catalytic activity of 5-LOX was regulated by a variety of substances, including Ca2+, adenosine triphosphate (ATP) FLAP and kinase, which could effectively improve the catalytic activity of 5-LOX. In addition, FLAP is essential for activating 5-LOX. FLAP is a 5-LOX activating protein, which mainly exists in the endoplasmic omentum or nuclear membrane, and its molecular weight is 18 KD. When the cell was activated, the intracellular Ca2+ concentration began to increase, then 5-LOX changed its position in the cell and then combined with the small molecular membrane protein FLAP to play a catalytic role.
5-lipoxygenase (5-LOX) is an important kind of dioxygenase and a kind of LOX isozyme in organism. It is widely found in the tissues and blood of most mammals. The molecular weight of 5-lipoxygenase is 75 ~ 80kD, including 673 amino acids. 5-LOX mainly consists of two domains, of which the C2 domain, which is composed of 120 amino acids at the N-terminal, can bind to Ca2+, as well as a large catalytic domain. When stimulated by inflammatory factors, activated cytosolic phosphatase A2 (CPLA2) stimulated membrane phospholipid release of arachidonic acid (AA). At this point, the precursor compound AA will eventually produce leukotrienes (LTs) via the 5-LOX pathway. LTs is an important inflammatory mediator involved in many diseases such as atherosclerosis, cardiovascular disease, heart disease and other pathophysiological processes.
Agonist of 5-lipoxygenase
The catalytic activity of 5-LOX was regulated by a variety of substances, including Ca2+, adenosine triphosphate (ATP) FLAP and kinase, which could effectively improve the catalytic activity of 5-LOX. In addition, FLAP is essential for activating 5-LOX. FLAP is a 5-LOX activating protein, which mainly exists in the endoplasmic omentum or nuclear membrane, and its molecular weight is 18 KD. When the cell was activated, the intracellular Ca2+ concentration began to increase, then 5-LOX changed its position in the cell and then combined with the small molecular membrane protein FLAP to play a catalytic role.
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