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4MPD 4MPD 4MPD 4-MPD 4-MPD 4-MPD CAS 1373918-61-6

4MPD 4MPD 4MPD 4-MPD 4-MPD 4-MPD CAS 1373918-61-6

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Introduction

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4-Methylpentedrone (also known as 4-MPD and 4-Methyl-α-methylamino-valerophenone), is a stimulant drug of thecathinone class that has been sold online as a designer drug. It is a higher homologue of 4-Methylmethcathinone(Mephedrone) and 4-Methylbuphedrone (4-MeMABP), and the p-Methyl analogue of Pentedrone.

The monoamine transporter substrate and I hi it ion selectivity profiles of 4-MPD are unknown.

Another compound, 4-Methyl-N-Ethyl-Pentedrone (4-MEAP, 4-MEAPP) has been found to be incorrectly sold as 4-Methylpentedrone.



Systematic (IUPAC) name: 1-(4-Methylphenyl)-2-methylamino-pentan-1-one
CAS Number: 1373918-61-6
Formula: C13H19NO
Molar mass: 205.30 g·mol−1
4-MPD is an analogue of the cathinone pentedrone. 4-MPD features the addition of a methyl group to the para position of the aryl ring. It may also be described as a higher homologue of 4-methylbuphedrone and 4-methylmethcathinone (mephedrone).

The substituted cathinone class of compounds can be accurately called the beta-keto amphetamines. Cathinone itself is the primary psychoactive compound which can be extracted from the fresh leaves of Catha edulis otherwise known as Khat.

The difference in a cathinone and an amphetamine is small. Cathinones differ only by the presence of a ketone at the beta carbon.

The basic structure of the cathinone is a phenethylamine backbone with an alkyl substituent at the alpha carbon and a ketone at the beta carbon. This basic structure is modified in a number of predictable ways which are substitution on the aromatic ring, alkylation of the nitrogen or inclusion of the nitrogen atom in a ring structure and finally variation of the alkyl substituent at the alpha carbon.

One or more of these substitutions produces a unique cathinone. Hundreds have in fact been produced in the last decade in an ongoing attempt to evade the drug legislation in countries that do not practice legislation tackling all analogues or homologues. The cathinones are nearly all N-alkylated and quite a lot have ring substitutions.

Methylpentedrone specifically has a methyl substituent at the para position on the aryl ring, a methyl alkylation at the nitrogen and a propyl alkyl substituent at the alpha carbon.



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