Introduction
An Overview of 15-PGDH
15-hydroxy prostaglandin dehydrogenase (15-PGDH) is an important rate limiting enzyme for PG degradation and an inhibitor of COX-2. The 15-PGDH gene is located on the 4q34~q35 of chromosome 4, which is about 31KB, and there are 7 exons, and the molecular weight is 29kD, which can catalyze the conversion of 15-PGDH into a 15- ketone metabolite with greatly reduced activity. 15-PGDH is divided into two subtypes: nicotinamide adenine dinucleotide NAD+ dependent 15-PGDH (type I) and NADP+ dependent 15-PGDH (type II). 15-PGDH is widely found in normal tissues such as the lungs, kidneys, gastrointestinal tract, thyroid, prostate and placenta in mammals. Degradation of other nonprostaglandin polycyclic aromatic hydrocarbons in the presence of NAD+ coenzyme factors. The oxidation reaction can prevent the occurrence and development of tumor by reducing the carcinogens and procarcinogens produced under physiological or pathological conditions.
Inhibition of 15-PGDH
15-PGDH can be inhibited by some pharmacological drugs in multiple steps. SW033291 is an effective small molecular inhibitor of 15-PGDH with a Ki value of 0.1 nm and a tissue repair function. SW033291 can inhibit 15-PGDH in a non-competitive manner.
15-hydroxy prostaglandin dehydrogenase (15-PGDH) is an important rate limiting enzyme for PG degradation and an inhibitor of COX-2. The 15-PGDH gene is located on the 4q34~q35 of chromosome 4, which is about 31KB, and there are 7 exons, and the molecular weight is 29kD, which can catalyze the conversion of 15-PGDH into a 15- ketone metabolite with greatly reduced activity. 15-PGDH is divided into two subtypes: nicotinamide adenine dinucleotide NAD+ dependent 15-PGDH (type I) and NADP+ dependent 15-PGDH (type II). 15-PGDH is widely found in normal tissues such as the lungs, kidneys, gastrointestinal tract, thyroid, prostate and placenta in mammals. Degradation of other nonprostaglandin polycyclic aromatic hydrocarbons in the presence of NAD+ coenzyme factors. The oxidation reaction can prevent the occurrence and development of tumor by reducing the carcinogens and procarcinogens produced under physiological or pathological conditions.
Inhibition of 15-PGDH
15-PGDH can be inhibited by some pharmacological drugs in multiple steps. SW033291 is an effective small molecular inhibitor of 15-PGDH with a Ki value of 0.1 nm and a tissue repair function. SW033291 can inhibit 15-PGDH in a non-competitive manner.
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