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VEGF Signaling Pathway
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VEGF Signaling Pathway
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
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Vascular endothelial growth factor (VEGF) a specific mitogen isolated from endothelial cells by researchers in the late 20th century has been shown to have the ability to induce physiological and pathological angiogenesis. The VEGF family is a multifunctional cytokine that mainly includes six members VEGF-A VEGF-B VEGF-C VEGF-D VEGF-E and placental growth factor (PLGF). In many tumors the level of expression is related to the degree of malignancy of the tumor. Mammalian angiogenesis begins with the formation of an embryonic vascular network. Under the induction of hypoxia or inflammatory disease pro-angiogenic factors such as VEGF bFGF and PDGF are produced... read more
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