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Thymidylate synthetase (EC 2.1.1.45) is the enzyme used to generate thymidine monophosphate (dTMP) which is subsequently phosphorylated to thymidine triphosphate for use in DNA synthesis and repair. 5 10-methylenetetrahydrofolate dUMP dihydrofolate dTMP By means of reductive methylation deoxyuridine monophosphate (dUMP) and N5 N10-methylene tetrahydrofolate are together used to form dTMP yielding dihydrofolate as a secondary product. This provides the sole de novo pathway for production of dTMP and is the only enzyme in folate metabolism in which the 5 10-methylenetetrahydrofolate is oxidised during one-carbon transfer. The enzyme is essential for regulating the balanced supply of the 4 DNA precursors in... read more
Thymidylate synthetase (EC 2.1.1.45) is the enzyme used to generate thymidine monophosphate (dTMP) which is subsequently phosphorylated to thymidine triphosphate for use in DNA synthesis and repair. 5 10-methylenetetrahydrofolate dUMP dihydrofolate dTMP By means of reductive methylation deoxyuridine monophosphate (dUMP) and N5 N10-methylene tetrahydrofolate are together used to form dTMP yielding dihydrofolate as a secondary product. This provides the sole de novo pathway for production of dTMP and is the only enzyme in folate metabolism in which the 5 10-methylenetetrahydrofolate is oxidised during one-carbon transfer. The enzyme is essential for regulating the balanced supply of the 4 DNA precursors in... read more
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