Protein Analysis
16 RESULTS WITHIN anywhere FROM https:, Australia
Distance: 12,798.63km
shirley, NY USA, Accord
Tel: 1782281233
S-Nitrosylation refers to a covalent attachment of an NO moiety to sulfhydryl residues of proteins. The sulfhydryl residues belongs to a subset of specific cysteine residues in proteins the resulting SNO is an S-nitrosoprotein. SNOs have a short half-life in the cytoplasm because of the host of reducing enzymes including glutathione (GSH) and thioredoxin that denitrosylate proteins. Therefore SNOs are often stored in membranes vesicles the interstitial space and lipophilic protein folds to protect them from denitrosylation. For example caspases which mediate apoptosis are stored in the mitochondrial intermembrane space as SNOs.... read more
Tel: 1782281233
S-Nitrosylation refers to a covalent attachment of an NO moiety to sulfhydryl residues of proteins. The sulfhydryl residues belongs to a subset of specific cysteine residues in proteins the resulting SNO is an S-nitrosoprotein. SNOs have a short half-life in the cytoplasm because of the host of reducing enzymes including glutathione (GSH) and thioredoxin that denitrosylate proteins. Therefore SNOs are often stored in membranes vesicles the interstitial space and lipophilic protein folds to protect them from denitrosylation. For example caspases which mediate apoptosis are stored in the mitochondrial intermembrane space as SNOs.... read more
Distance: 12,798.63km
45-1 Ramsey Road, Shirley, NY 11967, USA, shirley
SUMO modification (Small Ubiquitin-like Modifiers) is a kind of post-translational modification of protein. It has a variety of modification and processing forms and there are many types. SUMO modification mainly plays an important role in the assembly of nuclear proteins maintaining genome integrity and regulating intracellular signaling pathways. Mature protein drugs undergo a series of post-translational modifications and have specific biological activities. Naturally modified protein drugs need to determine the type of modification identify the site of modification and analyze the structure of the modification. And its specificity accuracy and stability were measured. Therefore according to the SUMO ubiquitination modification... read more
SUMO modification (Small Ubiquitin-like Modifiers) is a kind of post-translational modification of protein. It has a variety of modification and processing forms and there are many types. SUMO modification mainly plays an important role in the assembly of nuclear proteins maintaining genome integrity and regulating intracellular signaling pathways. Mature protein drugs undergo a series of post-translational modifications and have specific biological activities. Naturally modified protein drugs need to determine the type of modification identify the site of modification and analyze the structure of the modification. And its specificity accuracy and stability were measured. Therefore according to the SUMO ubiquitination modification... read more
Distance: 4,204.15km
45-16 Ramsey Road, New York
Tel: 1-631-626-9181
Creative Proteomics provides a comprehensive range of proteomics services using both gel-based and gel-free proteome analysis platforms. We have integrated a set of protein separation characterization identification and quantification systems into our proteomics workstation which is featured with high throughput and super-sensitivity. We offer quality proteomics services for target identification lead optimization and preclinical and clinical phases of drug development. Of note Creative Proteomics is staffed by specialists who have extensive experience in handling hard-to-analyze samples such as plasma membrane serum cerebrospinal fluid. In addition we are also professional in studying protein modification and protein-protein interaction. Moreover a series of... read more
Tel: 1-631-626-9181
Creative Proteomics provides a comprehensive range of proteomics services using both gel-based and gel-free proteome analysis platforms. We have integrated a set of protein separation characterization identification and quantification systems into our proteomics workstation which is featured with high throughput and super-sensitivity. We offer quality proteomics services for target identification lead optimization and preclinical and clinical phases of drug development. Of note Creative Proteomics is staffed by specialists who have extensive experience in handling hard-to-analyze samples such as plasma membrane serum cerebrospinal fluid. In addition we are also professional in studying protein modification and protein-protein interaction. Moreover a series of... read more
Distance: 12,798.63km
45-1 Ramsey Road, Shirley, NY 11967, USA, shirley
Tel: +1 6316197922
Protein methylation is a post-translational modification process in which proteins are modified by an addition of methyl groups by S-adenosylmethionine dependent methyltransferases with S-adenosyl methionine (SAM) as the primary donor of methyl group. Methylation of proteins can occur on multiple amino acids on proteins including arginine lysine histidine etc. Methylation is mediated by methyltransferases Methylation of lysine involves the addition of one to three methyl groups on the amino acid's ε-amine group to form mono- di- or tri-methyllysine. This modification often occurs in a conserved sequence motif on proteins. For example two typical motifs are RGG box and RXR sequence.... read more
Tel: +1 6316197922
Protein methylation is a post-translational modification process in which proteins are modified by an addition of methyl groups by S-adenosylmethionine dependent methyltransferases with S-adenosyl methionine (SAM) as the primary donor of methyl group. Methylation of proteins can occur on multiple amino acids on proteins including arginine lysine histidine etc. Methylation is mediated by methyltransferases Methylation of lysine involves the addition of one to three methyl groups on the amino acid's ε-amine group to form mono- di- or tri-methyllysine. This modification often occurs in a conserved sequence motif on proteins. For example two typical motifs are RGG box and RXR sequence.... read more
Distance: 12,798.63km
45-1 Ramsey Road, Shirley, NY 11967, USA, shirley
The sequence of peptide/protein is important to study the biological function of the peptide/protein. However complete characterization of peptides/proteins including post-translational modifications (PTMs) sequence mutations and variants is very challenging. There are two approaches to determine the sequence of peptide/protein by mass spectrometry: database search and de novo sequencing. Database search approach compares acquired mass spectra to a database of known protein sequences to identify the protein sequences. De novo sequencing is a process in which amino acid sequences are directly interpreted from tandem mass spectra without the assistance of a database.... read more
The sequence of peptide/protein is important to study the biological function of the peptide/protein. However complete characterization of peptides/proteins including post-translational modifications (PTMs) sequence mutations and variants is very challenging. There are two approaches to determine the sequence of peptide/protein by mass spectrometry: database search and de novo sequencing. Database search approach compares acquired mass spectra to a database of known protein sequences to identify the protein sequences. De novo sequencing is a process in which amino acid sequences are directly interpreted from tandem mass spectra without the assistance of a database.... read more
Distance: 12,798.63km
45-1 Ramsey Road, Shirley, NY 11967, USA, Shirley
Tel: 6316197922
Host Cell Proteins (HCPs) are a heterogeneous complex group of proteins that derived from the host cell. HCPs differ significantly in molecular mass isoelectric point hydrophobic properties and structures. Figure 1 shows a harvested product pool of bacterial and mammalian fermentation by two-dimensional difference gel electrophoresis (2D-DIGE). Identification and quantification HCPs is very important in the development of biopharmaceutical products to ensure product purity and patient safety. Protease of HCPs can influence the protein pattern in culture and influence the purification process. In addition HCPs can undergo post-translational modifications that make quantification and characterization more difficult. Moreover high HCP variance... read more
Tel: 6316197922
Host Cell Proteins (HCPs) are a heterogeneous complex group of proteins that derived from the host cell. HCPs differ significantly in molecular mass isoelectric point hydrophobic properties and structures. Figure 1 shows a harvested product pool of bacterial and mammalian fermentation by two-dimensional difference gel electrophoresis (2D-DIGE). Identification and quantification HCPs is very important in the development of biopharmaceutical products to ensure product purity and patient safety. Protease of HCPs can influence the protein pattern in culture and influence the purification process. In addition HCPs can undergo post-translational modifications that make quantification and characterization more difficult. Moreover high HCP variance... read more
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