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7,171 RESULTS WITHIN anywhere FROM https:, United States
Distance: 12,798.63km
NY, NY
From single neuron down to single channel thanks to the different recording configurations (whole-cell perforated-patch cell-attached outside-out) patch-clamp techniques provide the highest resolution for electrophysiological recordings in ion channel screening process. In Acroscell we provide manual and automated patch-clamp techniques for ion channel target scanning.... read more
From single neuron down to single channel thanks to the different recording configurations (whole-cell perforated-patch cell-attached outside-out) patch-clamp techniques provide the highest resolution for electrophysiological recordings in ion channel screening process. In Acroscell we provide manual and automated patch-clamp techniques for ion channel target scanning.... read more
Distance: 12,798.63km
NY, NY
Sodium channels are that form ion channels conducting sodium ions (Na+) through cellular plasma membrane. Voltage-gated sodium channels (also called "VGSCs" or "Nav channel") are present in the membrane of most excitable cells and are involved in many cardiac or neuronal diseases. Genetic mutations that cause persistent activity in sodium channels can cause disease by creating excessive activity of certain kinds of neurons. Mutations that interfere with Na+ channel inactivation can contribute to cardiovascular diseases or epileptic seizures by window currents which can cause muscle and/or nerve cells to become over-excited.... read more
Sodium channels are that form ion channels conducting sodium ions (Na+) through cellular plasma membrane. Voltage-gated sodium channels (also called "VGSCs" or "Nav channel") are present in the membrane of most excitable cells and are involved in many cardiac or neuronal diseases. Genetic mutations that cause persistent activity in sodium channels can cause disease by creating excessive activity of certain kinds of neurons. Mutations that interfere with Na+ channel inactivation can contribute to cardiovascular diseases or epileptic seizures by window currents which can cause muscle and/or nerve cells to become over-excited.... read more
Distance: 12,798.63km
NY, NY
Calcium channel have been well recognized as therapeutic targets for treating a number of diseases. However the calcium channel class is considered to be underexploited due to the lack of reliable functional cell-based assays for high-throughput screening. Here Acroscell utilizes automated patch-clamp technique to test various calcium channel activities with your compound treatment and digital cell Ca2+ imaging with fura-2 AM dye in single human living cells (primary cultured cells or stable-expressing cell lines). We also offer [Ca2+]i measurement to test effects of lead compounds on GPCR-mediated [Ca2+]i signaling pathway such as Ca-sensing receptor and other GPCR.... read more
Calcium channel have been well recognized as therapeutic targets for treating a number of diseases. However the calcium channel class is considered to be underexploited due to the lack of reliable functional cell-based assays for high-throughput screening. Here Acroscell utilizes automated patch-clamp technique to test various calcium channel activities with your compound treatment and digital cell Ca2+ imaging with fura-2 AM dye in single human living cells (primary cultured cells or stable-expressing cell lines). We also offer [Ca2+]i measurement to test effects of lead compounds on GPCR-mediated [Ca2+]i signaling pathway such as Ca-sensing receptor and other GPCR.... read more
Distance: 12,798.63km
NY, NY
Voltage-gated potassium channel plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The voltage-gated potassium channels are responsible for firing sustained trains of very brief action potentials at high frequency in pallidal neurons. Of particular importance in the field of drug safety are the voltage-gated potassium channels Kv11.1 (hERG) and Kv7.1 (KCNQ1) which are associated with the potentially fatal Long QT Syndrome.... read more
Voltage-gated potassium channel plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The voltage-gated potassium channels are responsible for firing sustained trains of very brief action potentials at high frequency in pallidal neurons. Of particular importance in the field of drug safety are the voltage-gated potassium channels Kv11.1 (hERG) and Kv7.1 (KCNQ1) which are associated with the potentially fatal Long QT Syndrome.... read more
Distance: 12,798.63km
NY, NY
Chloride Channels are a superfamily of poorly understood ion channels specific for chloride. Though the functions of CLC cytoplasmic domains are not fully characterized yet their importance is illustrated by the pathologies resulting from their mutations. Voltage-gated chloride channels display a variety of important physiological and cellular roles that include regulation of pH volume homeostasis organic solute transport cell migration cell proliferation and differentiation. Based on sequence homology the chloride channels can be subdivided into a number of groups.... read more
Chloride Channels are a superfamily of poorly understood ion channels specific for chloride. Though the functions of CLC cytoplasmic domains are not fully characterized yet their importance is illustrated by the pathologies resulting from their mutations. Voltage-gated chloride channels display a variety of important physiological and cellular roles that include regulation of pH volume homeostasis organic solute transport cell migration cell proliferation and differentiation. Based on sequence homology the chloride channels can be subdivided into a number of groups.... read more
Distance: 12,798.63km
NY, NY
Tel: 6316197922
Enzymes used for industrial applications are produced by contained fermentation in large closed fermentation tanks using a well-defined production strain. These production strains grow under specific conditions to maximize the amount of enzyme that they produce. When fermentation is complete the production strain cells are inactivated and removed by centrifugation/filtration separating the resulting enzyme from its production strain. The enzyme concentrate is then purified standardized and stabilized with diluents – delivering the liquid or granulated enzyme products depending on the application it will be used in.... read more
Tel: 6316197922
Enzymes used for industrial applications are produced by contained fermentation in large closed fermentation tanks using a well-defined production strain. These production strains grow under specific conditions to maximize the amount of enzyme that they produce. When fermentation is complete the production strain cells are inactivated and removed by centrifugation/filtration separating the resulting enzyme from its production strain. The enzyme concentrate is then purified standardized and stabilized with diluents – delivering the liquid or granulated enzyme products depending on the application it will be used in.... read more
Distance: 12,798.63km
NY, NY
Tel: 6316197922
Microbiosci provides the most advanced facilities capabilities and expertise to accelerate the development demonstration and commercialization of microbial technologies. Our world-class facility is equipped to work with a range of biosafety level one (BSL-1) expression systems. Microbiosci specializes in providing sophisticated downstream processing formulation fill/finish and release testing services including GMP. With our unparalleled experience cutting-edge facilities commitment to quality innovative nature and dedicated project management Microbiosci helps your fermentation product reach its full potential whether for small-scale development projects or commercial-scale market leadership. Microbiosci's integrated fermentation and purification development and analytical development teams work together to achieve program goals... read more
Tel: 6316197922
Microbiosci provides the most advanced facilities capabilities and expertise to accelerate the development demonstration and commercialization of microbial technologies. Our world-class facility is equipped to work with a range of biosafety level one (BSL-1) expression systems. Microbiosci specializes in providing sophisticated downstream processing formulation fill/finish and release testing services including GMP. With our unparalleled experience cutting-edge facilities commitment to quality innovative nature and dedicated project management Microbiosci helps your fermentation product reach its full potential whether for small-scale development projects or commercial-scale market leadership. Microbiosci's integrated fermentation and purification development and analytical development teams work together to achieve program goals... read more
Distance: 12,798.63km
NY, NY
Tel: 6316197922
With the rapid evolution of genomics transcriptomics proteomics and metabolomics the industrial application of microbial systems offers tremendous potential to heal feed and fuel the world. Fermentation technologies use a broad spectrum of microbial hosts to produce a wide variety of biopharmaceuticals including interferon hormones cytokins blood products enzymes and vaccines. As a premier research-assist institution Microbiosci has extensive experience in the characterization of microbial cell bank for pharmaceutical products pesticides veterinary medicines and industrial enzymes.... read more
Tel: 6316197922
With the rapid evolution of genomics transcriptomics proteomics and metabolomics the industrial application of microbial systems offers tremendous potential to heal feed and fuel the world. Fermentation technologies use a broad spectrum of microbial hosts to produce a wide variety of biopharmaceuticals including interferon hormones cytokins blood products enzymes and vaccines. As a premier research-assist institution Microbiosci has extensive experience in the characterization of microbial cell bank for pharmaceutical products pesticides veterinary medicines and industrial enzymes.... read more
Distance: 12,798.63km
NY, NY
Current Good Manufacturing Practice (cGMP) regulation guarantees the safety of microbial fermentation process with critical requirements. With years of experience in microbial fermentation development Microbiosci is dedicated to provide customized microbial cGMP fermentation services to meet different needs. Microbiosci's integrated microbial fermentation platform consists of dedicated process development systems large-scale facilities and quality control technology. The Current Good Manufacturing Practice (cGMP) is a latest system designed to minimize the contamination risk from raw materials environment and equipment to the training of staffs. It also avoids the production of unwanted by-products.... read more
Current Good Manufacturing Practice (cGMP) regulation guarantees the safety of microbial fermentation process with critical requirements. With years of experience in microbial fermentation development Microbiosci is dedicated to provide customized microbial cGMP fermentation services to meet different needs. Microbiosci's integrated microbial fermentation platform consists of dedicated process development systems large-scale facilities and quality control technology. The Current Good Manufacturing Practice (cGMP) is a latest system designed to minimize the contamination risk from raw materials environment and equipment to the training of staffs. It also avoids the production of unwanted by-products.... read more
Distance: 12,798.63km
NY, NY
Microbiosci is one of only a few suppliers that have expertise with microbial manufacturing in an industrial scale. Combined with extensive biomanufacturing experience we have ability to transfer development technology of any stage e.g. customer lab process or pilot trials or larger scale experience into our assets. We offer full-scale microbial fermentation services and management through equipment selection to products formulation and packaging. We also own the capacity to deal with emerging problems and maintain the supply chain. If you have prepared your starting materials including specific microbes or culture medium we can design a comprehensive biomanufacturing process tailored to... read more
Microbiosci is one of only a few suppliers that have expertise with microbial manufacturing in an industrial scale. Combined with extensive biomanufacturing experience we have ability to transfer development technology of any stage e.g. customer lab process or pilot trials or larger scale experience into our assets. We offer full-scale microbial fermentation services and management through equipment selection to products formulation and packaging. We also own the capacity to deal with emerging problems and maintain the supply chain. If you have prepared your starting materials including specific microbes or culture medium we can design a comprehensive biomanufacturing process tailored to... read more
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