GPCR Signaling Pathway
1 RESULTS
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Introduction The G protein-coupled receptor (GPCR) family is the largest family of membrane proteins in eukaryotes. It encodes at least 800 human genes. But endogenous ligands of more than 140 GPCRs have not been determined. Such GPCRs are referred to as orphan GPCRs (oGPCRs). A variety of extracellular signals or specific ligands can bind to GPCRs activate G-protein heterotrimers and downstream second messengers. They play an important role in a variety of physiological and pathological processes such as behavior vision and tumorigenesis. GPCR Structure The GPCR has seven transmembrane α-helical stereostructures. The amino terminus of the peptide chain is located... read more
Introduction The G protein-coupled receptor (GPCR) family is the largest family of membrane proteins in eukaryotes. It encodes at least 800 human genes. But endogenous ligands of more than 140 GPCRs have not been determined. Such GPCRs are referred to as orphan GPCRs (oGPCRs). A variety of extracellular signals or specific ligands can bind to GPCRs activate G-protein heterotrimers and downstream second messengers. They play an important role in a variety of physiological and pathological processes such as behavior vision and tumorigenesis. GPCR Structure The GPCR has seven transmembrane α-helical stereostructures. The amino terminus of the peptide chain is located... read more
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